abstract：:Restoration of cellular microenvironment is important in the treatment of neurodegenerative diseases for optimal functioning and survival of neurons. Oxidative stress has been proposed as one of the major pathogenic drivers in Parkinson's disease. Parkinson's model was developed by chronic administration of a pesticid...

journal_title：Neuroscience letters

authors： Bandookwala M,Sahu AK,Thakkar D,Sharma M,Khairnar A,Sengupta P

更新日期：2019-10-15 00:00:00

abstract：OBJECTIVE:Mesenchymal stem cells (MSCs) are widely used in regeneration and repair of various tissues and organs, and whether MSC-conditioned medium (MSC-CM) has protective effects in postoperative cognitive dysfunction (POCD) remains largely unknown. We aimed to assess the therapeutic effect and explore the mechanisms...

journal_title：Neuroscience letters

authors： Jiang Y,Gao H,Yuan H,Xu H,Tian M,Du G,Xie W

更新日期：2019-09-14 00:00:00

abstract：:Female sex hormone, progesterone, in addition to seizure modifying activity is also known as a potential protective agent against various brain injury conditions. Considering the predisposal role of traumatic brain injury (TBI) on developing post-traumatic epilepsy (PTE), the effect of progesterone on post-traumatic e...

journal_title：Neuroscience letters

authors： Ghadiri T,Vakilzadeh G,Hajali V,Khodagholi F

更新日期：2019-09-14 00:00:00

abstract：:Hearing impairment affects 1 in 500 newborns worldwide and nearly one out of three people over the age of 65 (WHO, 2019). Hereditary hearing loss is the most common type of congenital deafness; genetic factors also affect deafness susceptibility. Gene therapies may preserve or restore natural sound perception, and hav...

journal_title：Neuroscience letters

authors： Kang W,Sun Z,Zhao X,Wang X,Tao Y,Wu H

更新日期：2019-09-14 00:00:00

abstract：:Parkinson's disease (PD) is defined as a chronic neurodegenerative disorder which is diagnosed mostly by its clinical manifestations. Reactive oxygen species (ROS) are considered as key modulators in the development of PD. Despite the intensive investigations, antioxidant-dependent molecular mechanisms of initiation a...

journal_title：Neuroscience letters

authors： Hemmati-Dinarvand M,Saedi S,Valilo M,Kalantary-Charvadeh A,Alizadeh Sani M,Kargar R,Safari H,Samadi N

更新日期：2019-09-14 00:00:00

abstract：:Damaged axons in the adult central nervous system (CNS) fail to regenerate spontaneously due to several intrinsic and extrinsic factors that inhibit axon elongation. An extrinsic inhibitory factor, repulsive guidance molecule-a (RGMa), is upregulated around spinal cord lesion sites. Inhibition of RGMa using an antibod...

journal_title：Neuroscience letters

authors： Nakanishi T,Fujita Y,Tanaka T,Yamashita T

更新日期：2019-09-14 00:00:00

abstract：:Glia are key regulators of inflammatory responses within the central nervous system (CNS) following infection or trauma. We have previously demonstrated the ability of activated astrocytes to rapidly produce pro-inflammatory mediators followed by a transition to an anti-inflammatory cytokine production profile that in...

journal_title：Neuroscience letters

authors： Burmeister AR,Johnson MB,Marriott I

更新日期：2019-08-24 00:00:00

abstract：:Post-transcriptional control of gene expression by microRNAs provides an important regulatory system within neurons, allowing co-ordinate and fine-tuned expression of plasticity-related proteins. Indeed, specific microRNAs have been shown to be regulated by synaptic activity in the dentate gyrus, and contribute to the...

journal_title：Neuroscience letters

authors： Ryan B,Williams JM

更新日期：2019-08-10 00:00:00

abstract：:Identified in 1993, APOE4 is the greatest genetic risk factor for Alzheimer's disease (AD), increasing risk up to 15-fold compared to the common variant APOE3. Since the mid 1990's, transgenic (Tg) mice have been developed to model AD pathology and progression, primarily via expression of the familial AD (FAD) mutatio...

journal_title：Neuroscience letters

authors： Balu D,Karstens AJ,Loukenas E,Maldonado Weng J,York JM,Valencia-Olvera AC,LaDu MJ

更新日期：2019-08-10 00:00:00

abstract：:Nowadays, the style of living is restless and busy which has resulted in increased stress among many people. Stress causes various mental and health illness such as depression, anxiety, mood disorders, and aggressive behavior. Yoga and Sudarshan Kriya (SK) meditation are healthy ways to eradicate stress from people's ...

journal_title：Neuroscience letters

authors： Sharma H,Raj R,Juneja M

更新日期：2019-08-10 00:00:00

abstract：:This study aimed to investigate the effects of ghrelin, as a neuroprotective agent, on cognitive impairment and apoptosis pathway in methamphetamine-treated male rats. Sixty adult male Wistar rats were randomly divided into six groups (n = 10): Saline/Saline (SS), Saline/Ghrelin (SG), Methamphetamine/Simultaneous Sali...

journal_title：Neuroscience letters

authors： Fallahi S,Babri S,Farajdokht F,Ghiasi R,Soltani Zangbar H,Karimi P,Mohaddes G

更新日期：2019-08-10 00:00:00

abstract：:Imperceptible vibratory Gaussian noise stimulation to the periphery is frequently being applied to humans to enhance motor performance. It is commonly theorized that this stimulation creates a Stochastic Resonance-like effect across both sensory and motor systems, but this idea has no empirical support. In contrast, t...

journal_title：Neuroscience letters

authors： Tenan MS,Tweedell AJ,Haynes CA,Passaro AD

更新日期：2019-07-27 00:00:00

abstract：:Mutations in the glucocerebrosidase (GCase) gene (GBA) and GCase deficiency are major risk factors for Lewy body diseases. Decreased GCase activity enhances alpha-synuclein aggregation and disease development. Lysosomal integral membrane protein type 2, encoded by SCARB2, binds GCase targeting it to lysosomes and tran...

journal_title：Neuroscience letters

authors： Pérez-Roca L,Prada-Dacasa P,Segú-Vergés C,Gámez-Valero A,Serrano-Muñoz MA,Santos C,Beyer K

更新日期：2019-07-27 00:00:00

abstract：:Estrogens (E2) derived from ovaries and/or local de novo synthesis in the hippocampus profoundly regulate hippocampal structure and function, but the importance of local E2 versus ovarian E2 on hippocampal synaptic plasticity and spatial memory has not been well elucidated. The present study used ovariectomy (OVX) and...

journal_title：Neuroscience letters

authors： Liu M,Xing F,Bian C,Zhao Y,Zhao J,Liu Y,Zhang J

更新日期：2019-07-27 00:00:00

abstract：:Hearing loss is a common sensory disorder that affects more than 360 million people worldwide, and is primarily caused by the loss of hair cells (HCs). Ototoxic drugs, viral infections, genetic predisposition, aging or noise all damage HCs. 3β-hydroxysteroid-Δ24 reductase (DHCR24), one enzyme in the cholesterol biosyn...

journal_title：Neuroscience letters

authors： Tian KY,Chang HM,Wang J,Qi MH,Wang WL,Qiu Y,Liang K,Chen FQ,Zha DJ,Qiu JH

更新日期：2019-07-27 00:00:00

abstract：:Exercise increases the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus and beneficially contributes to cognitive function and is accompanied by epigenetic changes. Specifically, the activity levels of histone acetyltransferases (HATs) and histone deacetylases (HDACs) regulate histone acetylat...

journal_title：Neuroscience letters

authors： Li X,Inoue T,Hayashi M,Maejima H

更新日期：2019-07-27 00:00:00

abstract：:Pain is the most characteristic feature of sickle cell disease (SCD). Patients with SCD live with unpredictable, recurrent episodes of acute painful crisis, as well as chronic unremitting pain throughout their lifetime. While most of the research and medical efforts have focused on treating vaso-occlusion crisis and a...

journal_title：Neuroscience letters

authors： He Y,Wang ZJ

更新日期：2019-07-27 00:00:00

abstract：BACKGROUND:Parkinson's disease (PD) is the debilitating movement disorder, distinguished by dopaminergic and norepinephrinergic neurodegeneration. Apart from candidate gene mutations, several modifier loci have been reported to be associated with the disease manifestation. The Dopamine β-Hydroxylase (DBH) maintains cel...

journal_title：Neuroscience letters

authors： Ghosh A,Sadhukhan T,Giri S,Biswas A,Das SK,Ray K,Ray J

更新日期：2019-07-27 00:00:00

abstract：:An event-related decrease in alpha power contralateral to the presentation of a stimulus is now a well-established phenomenon. Two distinct accounts of the functional role of alpha changes are present in the literature that either focus on alpha changes observed during attentional or simple perceptual tasks. This stud...

journal_title：Neuroscience letters

authors： Silas J,Tipple A,Jones A

更新日期：2019-07-13 00:00:00

abstract：:Sickle cell disease (SCD) describes a group of disorders associated with a point mutation in the beta chain of hemoglobin. The mutation leads to the creation of sickle hemoglobin (HbS) and causes distortion of erythrocytes through polymerization under low oxygen, resulting in characteristic sickle red blood cells. Vas...

journal_title：Neuroscience letters

authors： Uhelski ML,Simone DA

更新日期：2019-07-13 00:00:00

abstract：:Hyperacusis may be defined as diminishing tolerance to moderate and high intensity sounds in people with normal hearing sensitivity. Serotonin plays a critical role in some of auditory tasks including startle reflex and prepulse inhibition. Serotonin deficiency can cause some diseases which can coincide with hyperacus...

journal_title：Neuroscience letters

authors： Farahani S,Nasirinezhad F,Danyali S,Jalaei S,Shahbazi A,Karimi M,Mokrian H

更新日期：2019-07-13 00:00:00

abstract：BACKGROUND AND PURPOSE:Studies demonstrated that oxidative damage decreased intracellular ATP level in astrocytes. However, the pathway mediated ATP level decrease is obscure. Our previous study found intracellular ATP could be released via lysosome exocytosis in astrocytes. Here, we explored whether lysosome exocytosi...

journal_title：Neuroscience letters

authors： Li Z,Gu Y,Wen R,Shen F,Tian HL,Yang GY,Zhang Z

更新日期：2019-07-13 00:00:00

abstract：:Alpha-synuclein (α-SYN) is found in peripheral autonomic neuronal network apart from brain in Parkinson's disease (PD). Nitrated α-SYN is an undesirable modification associated with oxidative and nitrative damage and has been found extensively in brain, gastrointestinal(GI) tract and blood cells in PD. We aim to inves...

journal_title：Neuroscience letters

authors： Ma LY,Gao LY,Li X,Ma HZ,Feng T

更新日期：2019-06-21 00:00:00

abstract：:Walking with different types of cueing/stimulus (i.e. auditory, visual) has been shown to alter gait variability, thus emerging as an innovative therapeutical tool to restore abnormal gait variability in clinical populations. However, the majority of the research in this area has focused on auditory stimuli while visu...

journal_title：Neuroscience letters

authors： Vaz JR,Groff BR,Rowen DA,Knarr BA,Stergiou N

更新日期：2019-06-21 00:00:00

abstract：:The CHRNA7 gene encoding the α7 nicotinic acetylcholine receptor (nAChR) has repeatedly been linked with schizophrenia and the P50 sensory gating deficit. The α7 nAChR is considered a promising drug target for treatment of cognitive dysfunction in schizophrenia and improves memory and executive functions in patients a...

journal_title：Neuroscience letters

authors： Dyrvig M,Mikkelsen JD,Lichota J

更新日期：2019-06-21 00:00:00

abstract：:Thyrotropin-releasing hormone (TRH) plays an important role in the regulation of energy balance. While the regulation of TRH in the paraventricular nucleus (PVN) in response to changes of energy balance has been well studied, how TRH is regulated in the dorsomedial hypothalamus (DMH) in maintaining energy homeostasis ...

journal_title：Neuroscience letters

authors： Zhang N,Zhang HY,Bi SA,Moran TH,Bi S

更新日期：2019-06-11 00:00:00

abstract：:In spite of systematic investigations, the existence of a specific cortex that could encode for the intensities of somatosensory stimuli, including within nociceptive ranges, is still a matter of debate. The present consensus is that pain is expressed in a distributed network made of thalamus, SII, insula, ACC, and, l...

journal_title：Neuroscience letters

authors： Peyron R,Fauchon C

更新日期：2019-05-29 00:00:00

abstract：:Pharmacological agents acting at alpha-2 adrenergic receptors are widely used in physiology and neuroscience research. Mounting evidence of their potential utility in clinical and experimental psychopharmacology, necessitates new models and novel model organisms for their screening. Here, we characterize behavioral ef...

journal_title：Neuroscience letters

authors： Sysoev YI,Meshalkina DA,Petrov DV,Okovityi SV,Musienko PE,Kalueff AV

更新日期：2019-05-14 00:00:00

abstract：:Around 200,000 veterans (up to 32% of those deployed) of the 1991 Gulf War (GW) suffer from GW illness (GWI), which is characterized by multiple deficits in cognitive, affective, sensory and nociception domains. In this study we employed resting state fMRI (rsfMRI) to map impairments in brain function in GWI with adva...

journal_title：Neuroscience letters

authors： Gopinath KS,Sakoglu U,Crosson BA,Haley RW

更新日期：2019-05-14 00:00:00

abstract：:Methamphetamine (METH) has been a worldwide health threat for years. Recent studies have reported that circular RNA (circRNA) are highly abundant and dynamically expressed in brain. However, connections between circRNA and METH-induced neurotoxicity remains indefinite. In the present study, primary cortical neurons we...

journal_title：Neuroscience letters

authors： Li J,Shi Q,Wang Q,Tan X,Pang K,Liu X,Zhu S,Xi K,Zhang J,Gao Q,Hu Y,Sun J

更新日期：2019-05-14 00:00:00

abstract：:Twenty years ago, Wolfe, Xia, and Selkoe identified two aspartate residues in Alzheimer's presenilin protein that constitute the active site of the γ-secretase complex. Mutations in the genes encoding amyloid precursor protein (APP) or presenilin (PS) cause early onset familial Alzheimer's disease (AD), and sequential...

journal_title：Neuroscience letters

authors： Xia W

更新日期：2019-05-14 00:00:00

abstract：:The extracellular signal-regulated kinase (ERK) is enriched in the central nervous system, including the dopamine responsive regions such as the striatum and medial prefrontal cortex (mPFC). The kinase is sensitive to changing cellular and synaptic input and is implicated in the regulation of synaptic transmission and...

journal_title：Neuroscience letters

authors： Mao LM,Wang JQ

更新日期：2019-04-23 00:00:00

abstract：:Assessing the result of conceptual change (i.e., whether an individual has come to correctly understand a science concept) is important in science education, however traditional assessment methods lack objectivity. In this study, permutation entropy (PE) based complexity, a kind of entropy used to quantify the complex...

journal_title：Neuroscience letters

authors： Jin L,Jia H,Li H,Yu D

更新日期：2019-04-23 00:00:00

abstract：:Compromised oxygen supply to cerebral tissue could be an important mechanism contributing to age-related cognition decline. We recently showed in awake mice that resting cerebral tissue pO2 decreases with age, a phenomenon that manifests mainly after middle-age. To extend these findings, here we aimed to study how tis...

journal_title：Neuroscience letters

authors： Moeini M,Lu X,Bélanger S,Picard F,Boas D,Kakkar A,Lesage F

更新日期：2019-04-23 00:00:00

abstract：:Activations of the DLPFC and SMA have been shown to correlate with dual-task walking. However, very few investigations have directly perturbed the activations of these areas to establish a cause-and-effect relationship. The objectives of this study were: 1) to investigate the role of DLPFC and SMA in dual-task walking...

journal_title：Neuroscience letters

authors： Goh HT,Ewing S,Marchuk D,Newton A,Nyangani I

更新日期：2019-04-17 00:00:00

abstract：:Chewing and walking are two oscillatory behaviors performed on an everyday basis. The current study examined the impact chewing at different speeds (i.e. fast, slow, preferred) had on walking performance for fifteen young healthy adults (23.2 + 4.2 years) and fifteen healthy older participants (66.5 + 3.2 years). Chew...

journal_title：Neuroscience letters

authors： Samulski B,Prebor J,Armitano C,Morrison S

更新日期：2019-04-17 00:00:00

abstract：:This study investigated the interaction between physical activity level and responses to transcutaneous spinal direct current stimulation (tsDCS) as reflected in changes in pressure pain threshold (PPT) in the lower extremity. Participants (n = 35, 15 males) consisted of physically active young adults. PPTs were deter...

journal_title：Neuroscience letters

authors： Gibson J,Tremblay F

更新日期：2019-04-17 00:00:00

abstract：:Continuous use of crack induces hyperalgesia which is related to drug tolerance. Despite cumulative evidence based on the growth rate of crack abuse, no serious study has been focused on the mechanisms of crack-induced hyperalgesia. This study aimed to elucidate whether extracellular signal-regulated kinases (Erk1/2)/...

journal_title：Neuroscience letters

authors： Aberoumandi SM,Vousooghi N,Tabrizi BA,Karimi P

更新日期：2019-04-17 00:00:00

abstract：:Age-related neurodegenerative diseases are of critical concern to the general population and research/medical community due to their health impact and socioeconomic consequences. A feature of most, if not all, neurodegenerative disorders is the presence of proteinopathies, in which misfolded or conformationally altere...

journal_title：Neuroscience letters

authors： Chung KM,Hernández N,Sproul AA,Yu WH

更新日期：2019-04-01 00:00:00

abstract：:Parkinson's disease (PD) is a common neurodegenerative disease characterized pathologically by the selective loss of dopaminergic neurons in the substantia nigra and the intracellular accumulation of α-synuclein in the Lewy bodies. While the pathogenic mechanisms of PD are poorly understood, many lines of evidence poi...

journal_title：Neuroscience letters

authors： Sheehan P,Yue Z

更新日期：2019-04-01 00:00:00